Dr. György Buzsáki
Rutgers University, US
Since NeuroNexus began fabricating probes with high reliability and reasonable costs, we virtually stopped using wire electrodes and monitor electrical activity with silicon probes. It is a one-way process: once one begins to record with silicon probes, he/she never goes back to wires. ~Dr. György Buzsáki
Dr. Buzsáki’s group records large numbers of neurons simultaneously in the hippocampus and various cortical and subcortical structures for understanding how information is transferred across networks. He has designed seven custom probes through NeuroNexus that he uses to determine the geometrical distribution of extracellular currents, so that spiking activity can be related to the global behavior of the circuits.
The Buzsaki32 and Buzsaki64 designs have become Dr. Buzsáki’s workhorse probes. They were designed to record and segregate neurons in areas of packed cell densities as in the hippocampus and various neocortical layers. The inter-shank intervals allow for high-density sampling yet neighboring shanks record from independent populations. These custom designs allow for recording from representative samples of neurons in local circuits and monitoring of neuronal interactions with high temporal precision.
Many of Dr. Buzsáki’s probes have become popular catalog designs. He continues to push the envelope of the NeuroNexus design space as evidenced by his most recent design, a 256-channel probe which incorporates minimum feature sizes.
Computer rendering of a multi-shank Buzsaki probe design:
Wideband recording from a Buzsaki64 probe. The lower plot show 8-channels of recording from one shank:
Histology data from an 8-shank Buzsak64 probe: