Dr. Liset Menendez de la PridaInstituto Cajal CSIC, Madrid Spain
Both single-cell activity and field potential population events can be easily recorded. The linear array allows for propagation studies both in vitro and in vivo and it can be used for current source density analysis in slices.~Dr. Menendez de la Prida
Dr. Menendez de la Prida is interested in performing linear array recordings to understand the generating mechanisms of brain oscillations. She designed a 16-channel comb silicon probe that can be used for both in vitro and in vivo applications. It allows current source density analysis of field potential events in slices, but is also used to record activity from different orientations. In vivo, it can be used for propagation studies or topographic localization of sensory responses.
Dr. Menendez de la Prida has mostly used her design for in vitro studies. Use of the probe has revealed extremely useful information. Both single-cell and local field potential activity can be simultaneously recorded. The probe easily penetrates the slice and it can be repositioned several times over the course of a single experiment.
Several users have requested this design for similiar applications and it is now part of the NeuroNexus catalog. The electrode design is available in the catalog as special order. (Contact us for more information.)
Propagation studies of one type of population activity recorded from rat hippocampal slices: