Enhanced Burst-Suppression and Disruption of Local Field Potential Synchrony in a Mouse Model of Focal Cortical Dysplasia Exhibiting Spike-Wave Seizures
ANIMAL MODEL: Mouse, focal cortical dysplasias
EXPERIMENT: Acute, Epilepsy/Seizure focus
This paper evaluates aberrant brain neurophysiology, specifically focal cortical dysplasias (FCDs), which are common causes of brain seizures and often associated with intractable epilepsy. FCD was induced in a mouse model by neonatal freeze lesions (FLs) near the primary somatosensory cortex (S1). Linear multi-electrode arrays were used to record near the FL. Results indicated that FL animals exhibit a high prevalence of spontaneous spike-wave discharges, predominantly during sleep, and an increase in the incidence of hyper-excitable burst/suppression activity under general anesthesia. The paper concludes that monitoring the altered electrophysiology of burst activity under general anesthesia with multi-dimensional micro-electrode arrays may serve to define distinct neurophysiological biomarkers of epileptogenesis in human brain and improve techniques for surgical resection of epileptogenic malformed brain tissue.