NeuroNexus A1x16-5mm-100-703-H16_21mm probes were chronically implanted by Christos Lisgaras and Helen Scharfman at the Nathan S. Kline Institute for continuous LFP recordings over 3 days in mouse models of Alzheimer’s Disease. The 100-um site spacing of the linear probe spanned a single track through cortex, hippocampus and dentate gyrus (DG). They performed current source density (CSD) analysis on recordings from episodes of interictal spikes (IIS) along this axis with results suggesting that the dominant activity during IIS is in DG, and that IIS could be modulated by medial septum (MS).
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Alberto Sanchez-Aguilera and Mariam Masmudi-Martin et al. with the Liset Menendez de la Prida and Manuel Valiente labs have published in Cancer Cell. NeuroNexus A1x16-5mm-100-413-A16 silicon probes were used for repeated, simultaneous acute recordings in cortex and hippocampus of mouse models of brain metastasis. Detection of sharp-wave ripples and theta oscillations enabled localization of the probe in the CA1 target. Measurement of LFPs in both areas was used to identify neural activity patterns that could help predict the presence and type of metastasis in the brain.
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Two NeuroNexus A4x2-tet-5mm-150-200-121-CM32 probes were implanted chronically in adult Long-Evans rats to target the prefrontal cortex and hippocampus simultaneously. Maanasa Jayachandran et al. with Timothy Allen’s group at Florida International University show a successful method of stabilizing rigid chronic probes.
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