This publication in Neuron is a collaboration between Dr. Li-Huei Tsai at MIT and Dr. Thomas McHugh at Riken. Adaikkan et al. chronically implanted two NeuroNexus A1x16-3mm-50-177-CM16LP probes, targeting bilateral mouse visual cortex (V1) for its role in novelty discrimination. They recorded LFP, multi-unit (MUA) and single-unit activity from freely moving animals including 5XFAD and Tau P301S mice to study cross-hemispheric (CH) signaling and its impairment in models of neurodegeneration. They found that interhemispheric synchronization, and thus novelty discrimination, is impaired by unilateral inhibition or dysfunction of CH neurons.
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Warren Grill’s group at Duke University used NeuroNexus 16- and 32-channel single-shank polytrodes to test their computational model of spinal cord stimulation (SCS) in vivo. They performed acute recordings in the rat dorsal horn and identified individual neurons with responses to various levels of mechanical stimulation of the paw with and without SCS. John Gilbert et al. results in Brain Stimulation suggest that the temporal regularity, or lack thereof, of SCS can be tuned for efficacy, and that pain relief may be achieved not only by overall inhibition of firing rates, but also by changes in firing patterns.
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In their Science Advances publication, Sohn et al. from Yoshiyuki Kubota’s group at the National Institute for Physiological Sciences (NIPS) in Japan and Matthew Larkum’s group at Charité in Berlin used NeuroNexus acute, 16-channel probes (A1x16-5mm-100-177-A16) to record M1 neurons during optogenetic inactivation of M2 in C57BL/6J mice. Electrode sites spanned 100µm to 1600µm below the pial surface. Their study characterizes two presynaptic connections involved in pyramidal neuron spine dynamics during motor learning. Transient spines appear and disappear at corticocortical connections, while new and enlarging spines appear at thalamocortical connections.
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