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Science Updates

Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models

Craft et al. recorded from the olfactory bulb (OB) of rats using NeuroNexus 32-channel probes (A4x2-tet design) to capture odor evoked spiking activity of putative mitral cells (MCs). They found significant differences in evoked firing rates and spike count covariances. Then, using data-driven models, they provided a framework for how the brain codes odors with different modes of olfaction.

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Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models
Science Updates

Orientation selectivity enhances context generalization and generative predictive coding in the hippocampus

George Dragoi’s lab at Yale University used chronically implanted Buzsaki64 probes to study populations of simultaneously recorded place cells in rats. Subject exploration of novel environments promoted response generalization, while accumulated experience over several weeks improved discriminability. The results suggest new schemes for how the brain encodes new experiences.

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Orientation selectivity enhances context generalization and generative predictive coding in the hippocampus
Science Updates

Closed-loop automated reaching apparatus (CLARA) for interrogating complex motor behaviors

Cristin Welle’s lab recently published their new system for integrating chronic, extracellular electrophysiology using NeuroNexus A1x16-3mm-100-177-CM16LP probes with video data to conduct closed-loop stimulation experiments. The linear array was implanted in the mouse motor cortex and captured spike data from all layers during freely moving reach behaviors. These recordings provided neural data to complement behavioral data such that reach-related activity could be extracted.

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Closed-loop automated reaching apparatus (CLARA) for interrogating complex motor behaviors