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Science Updates

Cortical organization due to trans-synaptic complexes

In this Nature Communications paper from Thomas Biederer’s group, the authors used NeuroNexus A1x16-5mm-50-177-A16 acute probes to span all layers of prelimbic and infralimbic cortical areas in head-fixed, awake behaving mice. They recorded hundreds of neurons across multiple penetrations covering ~0.5mm craniotomy and identified differences in multiunit activity patterns as well as individual broad spiking units in single and double knockout models for trans-synaptic complexes LRRTM1 and SynCAM 1.

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Cortical organization due to trans-synaptic complexes
Science Updates

Multi-unit neuronal activity and the BOLD response

To characterize multiunit activity during fMRI in unanaesthetized rats, Qingqing Zhang et al. from Nanying Zhang’s lab at Pennsylvania State University chronically implanted NeuroNexus A1x16 MRCM16LP MR-compatible probes to record in visual cortex with differential referencing. They compared electrophysiological recordings under the same conditions as fMRI experiments. Their results highlight that multi-unit activity dynamics, and not gamma-band power, best explains multi-phasic BOLD response to blue laser visual stimulation.

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Multi-unit neuronal activity and the BOLD response
Science Updates

Alterations of high-frequency stimulation

Yifan Hu et al. at Zhejiang University studied the effects of alterations of high-frequency stimulation (HFS), both antidromic (A-HFS) and orthodromic (O-HFS) to hippocampal CA1 in rat. They used NeuroNexus A1x16-Poly2-5mm-50-177 probes to record across the layers of CA1, which enabled identification of pyramidal neurons targeted by A-HFS and O-HFS. The results of the study showed significant changes in evoked activity when an additional pulse is added to change the inter-pulse interval during HFS. They suggest that this supports new stimulation design for neuromodulation therapy.

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Alterations of high-frequency stimulation