In this Nature Communications paper from Thomas Biederer’s group, the authors used NeuroNexus A1x16-5mm-50-177-A16 acute probes to span all layers of prelimbic and infralimbic cortical areas in head-fixed, awake behaving mice. They recorded hundreds of neurons across multiple penetrations covering ~0.5mm craniotomy and identified differences in multiunit activity patterns as well as individual broad spiking units in single and double knockout models for trans-synaptic complexes LRRTM1 and SynCAM 1.
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To characterize multiunit activity during fMRI in unanaesthetized rats, Qingqing Zhang et al. from Nanying Zhang’s lab at Pennsylvania State University chronically implanted NeuroNexus A1x16 MRCM16LP MR-compatible probes to record in visual cortex with differential referencing. They compared electrophysiological recordings under the same conditions as fMRI experiments. Their results highlight that multi-unit activity dynamics, and not gamma-band power, best explains multi-phasic BOLD response to blue laser visual stimulation.
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Yifan Hu et al. at Zhejiang University studied the effects of alterations of high-frequency stimulation (HFS), both antidromic (A-HFS) and orthodromic (O-HFS) to hippocampal CA1 in rat. They used NeuroNexus A1x16-Poly2-5mm-50-177 probes to record across the layers of CA1, which enabled identification of pyramidal neurons targeted by A-HFS and O-HFS. The results of the study showed significant changes in evoked activity when an additional pulse is added to change the inter-pulse interval during HFS. They suggest that this supports new stimulation design for neuromodulation therapy.
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