For in vivo ephys experiments performed with the NeuroNexus SmartBox Pro™ and Radiens™ Allego software, Marine Tessier et al. with Claudio Rivera’s groups at Aix Marseille University and the University of Helsinki used NeuroNexus A1x16-3mm-100-177-A16 probes. They recorded LFP and single-units of wide-spiking and narrow-spiking neurons in the hippocampus of mice subjected to controlled cortical impact (CCI) as a model of brain injury to study non-neuronal targets of bumetanide.
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A1x16-5mm-100-177-CM16LP probes from NeuroNexus spanned layers II/III to V/VI of the barrel field in rat somatosensory cortex (S1BF) to allow layer-specific analyses including CSD. Xunda Wang et al. with Ed X. Wu’s lab at the University of Hong Kong optogenetically-induced spindle activities from ventral posteromedial thalamus (VPM) and used fMRI together with electrophysiology to precisely probe and characterize the temporal and spatial properties of the spindle activities throughout the brain.
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NeuroNexus A1x16-Poly2-5mm-50s-177 probes were used for repeated recordings of both excitatory and inhibitory neurons in barrel cortex (S1) of trained mice performing a whisker stimulation detection task. The Poly2 layout of the probe enabled tetrode-like spike detection, with appropriate laminar span to consistently target layer 5 across animals. With this setup, Zhaoran Zhang and Edward Zagha at UC Riverside studied unit activity (92 total sessions, average 175 units per mouse) during opto-tagging in S1 and optogenetic suppression of whisker motor cortex (wMC). Their results in Nature Communications reveal that top-down modulation from motor cortex to sensory cortex contributes to suppression of distractor stimuli in sensory selection.
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