NeuroNexus A1x32-10mm-50-177-Z32 probes, compatible with TDT ZIF-Clip® headstages, were implanted in adult rat to study hippocampal-cortical communication in memory consolidation. Jaekyung Kim et al. with the San Francisco VA and Karunesh Ganguly’s lab at UCSF recorded single units and LFP activity in prefrontal cortex, hippocampus and M1 during training for a motor reach-to-grasp task and during sleep. Their results in Nature suggest two distinct stages of memory consolidation, one dependent on hippocampus, and one following “hippocampal disengagement” when memory is encoded in cortex.
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Fabio Boi et al. with Luca Berdondini’s lab at Fondazione Istituto Italiano di Tecnologia (IIT) presents SiNAPS 4-shank recordings during optogenetic stimulation. Large and repeatable coverage of the 1024-channel probe led to obtaining unexpected results across farther-reaching brain circuits. With the new technology, they were able to achieve a multi-target experiment with a single insertion.
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Fabio Boi et al. with Luca Berdondini’s lab at Fondazione Istituto Italiano di Tecnologia (IIT), in collaboration with Anton Sirota’s group at Ludwig-Maximilians-University of Munich, first showed 4-shank, 1024-channel SiNAPS recordings in awake behaving mice. The probe coverage enabled data collection from cortex, thalamus and hippocampus simultaneously. Excitingly, this probe design was developed within just months of the original 1-shank, 256-channel probe. Both designs are available now, to all, worldwide.
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