In their Nature Nanotechnology publication, Sara Cadoni et al. with Serge Picaud’s lab at INSERM inserted NeuroNexus A1x16-5mm-50-703-A16 acute probes at a 45-degree angle to the brain surface to record in rat visual cortex expressing ultrasound-sensitive proteins (e.g., MscL). Their experiments tested changes in visual system activity during high-frequency ultrasound stimulation, demonstrating a way to control activation of the brain that can be useful for BCI devices.
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NeuroNexus probes were used to measure activation of the inferior colliculus by optogenetic and/or electrical stimulation of the auditory nerve in chronically deafened mice. The A1x32-6mm-50-177-A32 probes used by Elise A Ajay et al. with teammates at the University of Melbourne and the Bionics Institute spanned the range of best frequencies encoded along the tonotopic axis and recorded single units during a range of stimulation parameters. Their results demonstrate that in addition to acute deafness studies, cochlear stimulation does benefit chronically deafened subjects.
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A1x16-Poly2-5mm-50Std-177-CM16[LP] NeuroNexus probes were used acutely in the transgenic mouse medial septum during optogenetic inhibition of somatostatin neurons thought to regulate hippocampal theta oscillations. Indeed, through recordings using NeuroNexus Buzsaki32-H32_21mm multi-shank probes positioned across CA1, Nelson Espinosa et al. with Pablo Fuentealba’s group at the Pontificia Universidad Católica de Chile confirmed that septal output influences theta amplitude and synchrony in the hippocampus.
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