Gian Nicola Angotzi et al. from Fondazione Istituto Italiano di Tecnologia (IIT) describe optimizing SiNAPS (Simultaneous Neural Active Pixel Sensor) probes for in vivo recordings. The paper shares data from acute spike and LFP recordings in rat somatosensory cortex.
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Lior J. Sukman and Eran Stark at Tel Aviv University created optoelectrodes with NeuroNexus Buzsaki32-H32_21mm probes for opto-tagging parvalbumin and pyramidal neurons in hippocampal CA1 and cortex of freely-moving mice. They directly tested and confirmed prior modeling results suggesting that different cell types have different spatial distribution of extracellular voltage during action potentials.
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In a transgenic mouse model of human pTau tauopathy, Tim J. Viney et al. in collaboration with co-authors David Bannerman and Peter Somogyi at the University of Oxford tested hippocampal pyramidal cells and their network. They used 3 styles of NeuroNexus acute 16-channel probes: A1x16-5mm-50-703-A16, A2x2-tet-10mm-150-150-121-A16, and Buzsaki16-A16 to record theta oscillations and sharp waves during a head-fixed behavioral task. Their results in Cell Reports show that Tau neurodegeneration most greatly affects deep-layer pyramidal neurons and that it spreads to oligodendrocytes, but that overall network function is unaffected.
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