CA1 pyramidal cells encode navigation task-relevant information

NeuroNexus high-density Poly3 acute probes (A1x32-Poly3-10mm-25s-177-A32 or A1x32-Poly3-5mm-25s-177-A32) were used to target all 32 recording sites to the CA1 layer of mouse hippocampus for recording individual pyramidal cell spikes. Probes were re-used for multiple sessions in different locations within a craniotomy on successive days. The results from Annabelle Singer’s group at Georgia Tech demonstrate that non-place cells distinguish correct and incorrect behavioral trials when spatial information encoded by place cells is ambiguous relative to the task. They also showed that this encoding does not function normally in a mouse model of Alzheimer’s Disease.

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