Clozapine for neural plasticity after stroke

Jongwook Cho et al and the Hyoung‑Ihl Kim group from Gwangju Institute of Science and Technology (GIST) in Korea published Translational Stroke Research. They used NeuroNexus A1x16-10mm-100-177-A16 probes to measure single-unit activity before and after a single dose of clozapine in a rat model of stroke. Recordings in the sensory-parietal cortex confirmed a significant and persistent increase in firing rate associated with DREADD-based chemogenetic neuromodulation. Results showing increases in markers of neural plasticity support clozapine as a viable option for post-stroke recovery treatment.

Related Topics