Cortical organization due to trans-synaptic complexes

In this Nature Communications paper from Thomas Biederer’s group, the authors used NeuroNexus A1x16-5mm-50-177-A16 acute probes to span all layers of prelimbic and infralimbic cortical areas in head-fixed, awake behaving mice. They recorded hundreds of neurons across multiple penetrations covering ~0.5mm craniotomy and identified differences in multiunit activity patterns as well as individual broad spiking units in single and double knockout models for trans-synaptic complexes LRRTM1 and SynCAM 1.