Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function

A recent study, “Differential Impacts of Germline and Adult Aggrecan Knockout in PV+ Neurons on Perineuronal Net Integrity and PV Cell Function,” explores how disrupting a key component of perineuronal nets (PNNs) affects parvalbumin-positive (PV+) interneurons and neural plasticity (Sverre Grødem, Kristian Kinden Lensjø). A NeuroNexus silicon probe (A1 × 32-5mm-25-177) allowed for precise measurement of electrophysiological properties in parvalbumin-positive interneurons, facilitating the investigation into how aggrecan knockout affects perineuronal net integrity and PV cell function.