Effects of human Tau in the hippocampus

In a transgenic mouse model of human pTau tauopathy, Tim J. Viney et al. in collaboration with co-authors David Bannerman and Peter Somogyi at the University of Oxford tested hippocampal pyramidal cells and their network. They used 3 styles of NeuroNexus acute 16-channel probes: A1x16-5mm-50-703-A16, A2x2-tet-10mm-150-150-121-A16, and Buzsaki16-A16 to record theta oscillations and sharp waves during a head-fixed behavioral task. Their results in Cell Reports show that Tau neurodegeneration most greatly affects deep-layer pyramidal neurons and that it spreads to oligodendrocytes, but that overall network function is unaffected.