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Hippocampus and cortex through task learning and consolidation

NeuroNexus A1x32-10mm-50-177-Z32 probes, compatible with TDT ZIF-Clip® headstages, were implanted in adult rat to study hippocampal-cortical communication in memory consolidation. Jaekyung Kim et al. with the San Francisco VA and Karunesh Ganguly’s lab at UCSF recorded single units and LFP activity in prefrontal cortex, hippocampus and M1 during training for a motor reach-to-grasp task and during sleep. Their results in Nature suggest two distinct stages of memory consolidation, one dependent on hippocampus, and one following “hippocampal disengagement” when memory is encoded in cortex.

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