Ketamine-induced neuroplasticity in the visual system

Ouelhazi Afef and Rudy Lussiez with Stéphane Molotchnikoff at the University of Montreal used NeuroNexus A1x16-5mm-100-177-A16 probes to record bilaterally in cat primary visual cortex. The linear design reached layer 2/3 and layer 5/6 simultaneously. Their experiment included both cat and mouse subjects, and measured orientation selectivity of single units before and after adaptation to a novel stimulus, and again after ketamine application. They characterized ketamine-induced changes in adaptation effects as well as microcircuit organization, including synchronization.