Multi-unit neuronal activity and the BOLD response

To characterize multiunit activity during fMRI in unanaesthetized rats, Qingqing Zhang et al. from Nanying Zhang’s lab at Pennsylvania State University chronically implanted NeuroNexus A1x16 MRCM16LP MR-compatible probes to record in visual cortex with differential referencing. They compared electrophysiological recordings under the same conditions as fMRI experiments. Their results highlight that multi-unit activity dynamics, and not gamma-band power, best explains multi-phasic BOLD response to blue laser visual stimulation.

Related Topics