Neural correlates of gastric and intestinal signaling

Single-unit recordings were conducted with 16-channel NeuroNexus probes (A2x2-tet-10mm-150-150-121-A16) in the lateral reticular formation (LRN) or the parasubthalamic nucleus (PSTn) of transgenic mice during stomach balloon inflation trials. The results in Cell from Zhang et al. and Ivan E de Araujo’s group at the Icahn School of Medicine at Mount Sinai revealed that LRN neurons detect gastric contractions and PSTn neurons respond to the presence of Glucagon-like peptide-1 (GLP-1). Their new understanding of a gut-brain sensorimotor circuit can help treat gastric disorders.