Perineuronal Nets in the Prefrontal Cortex of a Schizophrenia Mouse Model: Assessment of Neuroanatomical, Electrophysiological, and Behavioral Contributions

Sultana et al. used NeuroNexus acute probes to assess whether enzymatic digestion of Perineuronal nets (PNNs) in the prefrontal cortex (PFC) affected neural activity of DISC1 (Disruption in Schizophrenia) mutation mouse model. They found that following chondroitinase treatment, electrophysiological recordings from the PFC exhibited a reduced proportion of spontaneous, high-frequency firing neurons, and an increased proportion of irregularly firing neurons, with increased spike count and reduced interspike intervals in control animals.