Pharmacological and optical activation of TrkB in Parvalbumin interneurons regulate intrinsic states to orchestrate cortical plasticity

Winkel et al. used NeuroNexus Optoelectrode (A1x16-10 mm-100-177-OA16LP) and SmartBox neural interface processor to capture local field potential data from V1 of mice. They showed that TrkB activation in PV interneurons dynamically regulates the intrinsic properties of the same interneurons by decreasing their intrinsic excitability and switching the PV network into a plastic configuration, which orchestrates adult cortical plasticity states and mediates the effects of antidepressants on neuronal plasticity.