Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts

Gao et al. with Alexey Ponomarenko’s group in Berlin, Germany published in Nature Communications! NeuroNexus 32-channel linear probes and 8-shank probes were used to record single spikes and complex spike bursts in hippocampal CA1 neurons of awake behaving mice. Experimental manipulations included KCNQ3 genetic mutation affecting pyramidal cell M-type potassium channels and optogenetic disruption of up-stream circuitry. The paper parses out the factors contributing to coordination of spikes and bursts and how these may impact memory function.