Reactivation predicts the consolidation of unbiased long-term cognitive maps

Grosmark et al. from Columbia University published their findings in Nature Neuroscience. They implanted NeuroNexus Qtrodes into the CA1 hippocampus to collect pyramidal cell LFPs contralateral to calcium imaging in mice. They tracked hippocampal place cells over 2 weeks during both online spatial reward learning behavior and offline resting. Their results demonstrate long-lasting, context-specific reactivation of run-related hippocampal neural ensembles as well as the reinstatement of place-related neural sequences. Their findings suggest that post-learning offline memory consolidation plays a complementary and computationally distinct role in learning compared to online encoding.

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