Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior

The collaborative team of Ivan Soltesz from Stanford University, Attila Losonczy from Columbia University, Gyorgy Buzsaki from New York University and Z. Josh Huang from Cold Spring Harbor and Duke University recently published their results in Neuron. They implanted NeuroNexus Q-trodes (Q1x4-3mm-100-177-HQ4_21mm) for continuous monitoring of sharp wave-ripples in CA1 and 32-channel optoelectrode (A1x32-Poly3-10mm-50-177-OCM32LP) to measure blue light-evoked responses in CA1 of awake mice. Their results show that axo-axonic cells (AACs) are brain-state dependent and correlated with the onset of locomotion or whisking episodes. The postsynaptic effect of AACs on pyramidal cell spike generation is inhibitory and can remap place fields in the CA1 network.

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