Spinal cord stimulation parameters for maximal pain relief

Lee et al. from Nevro Corporation used NeuroNexus A4x4-3mm-50-125-177-A16 probes for acute, single-unit recordings during electrical stimulation in the rat dorsal spinal cord. Probe insertion targeted lamina II-III rostro-caudally along a single mediolateral position. Their findings suggest that simultaneous 10 kHz stimulation applied at a rostral location with 40 Hz stimulation applied at a caudal location has the greatest potential for clinical pain relief through maximal activation of inhibitory interneurons.