John M Barrett et al. in Gordon MG Shepherd’s lab at Northwestern University performed event-aligned analysis between high-resolution video of oromanual movements and spiking activity in the mouse cortex recorded with NeuroNexus A1x32-15mm-50-177-A32 probes. Through recordings and optogenetics experiments across motor cortex (M1) and in corresponding somatosensory cortex (S1), their results in Current Biology describe the anatomical and temporal organization of neural activity during forelimb movements pertaining to food handling.