V1 contextual responses depend on perceptual organization

Lisa Kirchberger et al. with Pieter Roelfsema’s group at the Netherlands Institute for Neuroscience used NeuroNexus A1x32-5mm-25-177-A32 acute probes localized by current source density analysis (CSD) in primary visual cortex (V1) of awake behaving mice. The laminar probe spanned the layers of V1 and recorded multi-unit activity, MUA, as well as individual units for receptive field (RF) characterization. Their results in Science Advances address cortical responses to contextual information outside the RF, which were most driven by disinhibitory VIP neurons and play a role in figure perception.