Lee et al. explored how the brainstem’s nucleus tractus solitarius (NTS) translates sensory stimulation into changes in blood pressure and heart rate. They found that groups of NTS neurons follow clear activity patterns that can be used to predict cardiovascular responses. This work led to the creation of a “digital twin” model for more precise control of internal organ function. The team used a NeuroNexus A1x16-Poly2s silicone probe to record neural activity in the NTS during their experiments.