This study examines the long-term effects of mild blast-induced traumatic brain injury (TBI) in rats, revealing increased gamma-band hyperexcitability and hyperconnectivity linked to the loss of somatostatin and parvalbumin inhibitory interneurons. Despite no significant white matter damage, researchers observed altered cortical activity, suggesting potential long-term cognitive impacts.
Using Neuronexus A32-channel microelectrode arrays, the team performed high-density EEG recordings, capturing precise neural activity changes in the cortex. These recordings enabled a detailed analysis of functional connectivity and excitatory-inhibitory imbalances following TBI.
The findings highlight the importance of long-term monitoring in TBI research and suggest potential therapeutic targets for restoring neural balance in affected individuals.
